ADA president urges members to join fight against opioids abuse

ADA President Carol Gomez Summerhays July 6 urged ADA member dentists everywhere to take steps to help prevent the widespread abuse of opioid pain medications, according to a Dear Colleague letter published in ADA News.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fjuly%2Fada-president-urges-members-to-join-fight-against-opioids-abuse&key=ddaed8f51db7bb1330a6f6de768a69b8

A MESSAGE FROM THE ADA PRESIDENT

We have all heard the stories of celebrities who have died from overdosing on prescription painkillers. The stories are tragic, and they are not limited to the rich and famous. In 2014, over 47,000 people died from drug overdoses, and 40 percent of those (18,893 deaths) involved opioid analgesics, according to the Centers for Disease Control and Prevention. This doesn't count the nearly 2 million Americans the Substance Abuse and Mental Health Services Administration said reported abusing or being dependent on prescription pain relievers.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fjuly%2Fa-message-from-the-ada-president&key=ddaed8f51db7bb1330a6f6de768a69b8

5 things that don't mix well with cocktails and beer

An icy cold beer or margarita may sound perfect with a long weekend barbecue, but some things don't blend well with alcohol

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2F5-things-that-dont-mix-well-with-cocktails-and-beer%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Intellectually disabled claim abuse, neglect in nursing homes

Homes for mentally disabled in Texas, elsewhere, are being called into question for abuse and negligence issues

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fabuse-of-intellectually-disabled-people-a-big-problem%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Beware of broken glow sticks on Independence Day

Poison control experts say broken glow sticks can be a health hazard in more ways than one

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Findependence-day-beware-of-broken-glow-sticks%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Zika and sex: New research and avoiding the risk

Fears continue about the spread of Zika, with mosquito season in full swing. The CDC says there are now more than 900 Zika cases in the U.S. Nearly all of them are linked to travel to affected areas or sexual transmission. Dr. David Agus joins "CBS This Morning" from Los Angeles to discuss a new report that suggests the virus may spread more frequently through sex than previously thought, and that women are at greater risk.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fzika-and-sex-new-research-and-avoiding-the-risk%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

A cereal cafe bowls over customers

New York City's landscape of trendy restaurants has added a new eatery that taps into the childhood memories of most Americans. The Kellogg's Cafe is offering bowls of cereal with a twist. Anna Werner reports.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fa-cereal-cafe-bowls-over-customers%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Report: Fears grow Zika virus could act like STD

Dangerous mosquito-born disease is already in the U.S., and a growing body of evidence suggests it spreads frequently through sex

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Freport-zika-virus-sex-transmitted-evidence-studies-std%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Young adults battling anxiety, depression speak out on suicide

The CDC says about 4,600 young lives are lost to suicide each year. This past week, the American Academy of Pediatrics issued new guidelines to help doctors identify at-risk patients. CBS News spoke with four young adults who have been battling anxiety and depression, including one woman who survived several suicide attempts.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fyoung-adults-battling-anxiety-depression-speak-out-on-suicide%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Young people speaking out, helping others with depression

As the U.S. suicide rate hits a 30-year high, some who've struggled with depression work to spread understanding and hope

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fdepression-suicide-risk-young-people-overcoming-mental-illness%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Preventing teen suicide, VP's cancer moonshot, fireworks safety

In this Morning Rounds, CBS News chief medical correspondent Dr. Jon LaPook looks at the new push against adolescent suicide, now the second leading cause of death for 15- to 19-year-olds. Also, CBS News contributor Dr. Holly Phillips joins Dr. LaPook on "CBS This Morning: Saturday" to discuss Vice President Joe Biden's cancer moonshot initiative and offer a safety reminder for handling fireworks ahead of the Fourth of July celebrations.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fpreventing-teen-suicide-vps-cancer-moonshot-fireworks-safety%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Guys and the pressure to be beach body perfect

"Body image concerns are common in boys and young men. It's an under recognized problem," expert says

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fguys-and-the-pressure-to-be-beach-body-perfect%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

CDC: Brain-eating amoeba found at whitewater center after teen's death

Systems at U.S. National Whitewater Center inadequate to kill a rare, brain-attacking organism blamed for killing Ohio teenager, CDC says

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fcdc-brain-eating-amoeba-found-at-whitewater-center-after-teens-death-lauren-seitz%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling

Hepatocellular carcinoma (HCC) is the most common hepatic malignancy and the third leading cause of cancer related deaths. Previous studies have implicated bile acids in pathogenesis of HCC, but the mechanisms are not known. We investigated the mechanisms of HCC tumor promotion by bile acids the diethylnitrosamine (DEN)-initiation-cholic acid (CA)-induced tumor promotion protocol in mice. The data show that 0.2% CA treatment resulted in threefold increase in number and size of DEN-induced liver tumors. All tumors observed in DEN-treated mice were well-differentiated HCCs. The HCCs observed in DEN-treated CA-fed mice exhibited extensive CD3-, CD20-, and CD45-positive inflammatory cell aggregates. Microarray-based global gene expression studies combined with Ingenuity Pathway Analysis revealed significant activation of NF-B and Nanog in the DEN-treated 0.2% CA-fed livers. Further studies showed significantly higher TNF-α and IL-1β mRNA, a marked increase in total and phosphorylated-p65 and phosphorylated IBα (degradation form) in livers of DEN-treated 0.2% CA-fed mice. Treatment of primary mouse hepatocytes with various bile acids showed significant induction of stemness genes including Nanog, KLF4, Sox2, and Oct4. Quantification of total and 20 specific bile acids in liver, and serum revealed a tumor-associated bile acid signature. Finally, quantification of total serum bile acids in normal, cirrhotic, and HCC human samples revealed increased bile acids in serum of cirrhotic and HCC patients. Taken together, these data indicate that bile acids are mechanistically involved pathogenesis of HCC and may promote HCC formation via activation of inflammatory signaling.

From: Sun, L., Beggs, K., Borude, P., Edwards, G., Bhushan, B., Walesky, C., Roy, N., Manley, M. W., Gunewardena, S., O'Neil, M., Li, H., Apte, U. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F1%2FG91%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Cellular zinc is required for intestinal epithelial barrier maintenance via the regulation of claudin-3 and occludin expression

Intracellular zinc is required for a variety of cell functions, but its precise roles in the maintenance of the intestinal tight junction (TJ) barrier remain unclear. The present study investigated the essential roles of intracellular zinc in the preservation of intestinal TJ integrity and the underlying molecular mechanisms. Depletion of intracellular zinc in both intestinal Caco-2 cells and mouse colons through the application of a cell-permeable zinc chelator N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) induced a disruption of the TJ barrier, as indicated by increased FITC-labeled dextran flux and decreased transepithelial electrical resistance. The TPEN-induced TJ disruption is associated with downregulation of two TJ proteins, occludin and claudin-3. Biotinylation of cell surface proteins revealed that the zinc depletion induced the proteolysis of occludin but not claudin-3. Occludin proteolysis was sensitive to the inhibition of calpain activity, and increased calpain activity was observed in the zinc-depleted cells. Although quantitative PCR analysis and promoter reporter assay have demonstrated that the zinc depletion-induced claudin-3 downregulation occurred at transcriptional levels, a site-directed mutation in the egr1 binding site in the claudin-3 promoter sequence induced loss of both the basal promoter activity and the TPEN-induced decreases. Reduced egr1 expression by a specific siRNA also inhibited claudin-3 expression and transepithelial electrical resistance maintenance in cells. This study shows that intracellular zinc has an essential role in the maintenance of the intestinal epithelial TJ barrier through regulation of occludin proteolysis and claudin-3 transcription.

From: Miyoshi, Y., Tanabe, S., Suzuki, T. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F1%2FG105%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8