Thursday, September 1, 2016

Malabsorption and intestinal adaptation after one anastomosis gastric bypass compared with Roux-en-Y gastric bypass in rats

The technically easier one-anastomosis (mini) gastric bypass (MGB) is associated with similar metabolic improvements and weight loss as the Roux-en-Y gastric bypass (RYGB). However, MGB is controversial and suspected to result in greater malabsorption than RYGB. In this study, we compared macronutrient absorption and intestinal adaptation after MGB or RYGB in rats. Body weight and food intake were monitored and glucose tolerance tests were performed in rats subjected to MGB, RYGB, or sham surgery. Carbohydrate, protein, and lipid absorption was determined by fecal analyses. Intestinal remodeling was evaluated by histology and immunohistochemistry. Peptide and amino acid transporter mRNA levels were measured in the remodeled intestinal mucosa and those of anorexigenic and orexigenic peptides in the hypothalamus. The MGB and RYGB surgeries both resulted in a reduction of body weight and an improvement of glucose tolerance relative to sham rats. Hypothalamic orexigenic neuropeptide gene expression was higher in MGB rats than in RYGB or sham rats. Fecal losses of calories and proteins were greater after MGB than RYGB or sham surgery. Intestinal hyperplasia occurred after MGB and RYGB with increased jejunum diameter, higher villi, and deeper crypts than in sham rats. Peptidase and peptide or amino acid transporter genes were overexpressed in jejunal mucosa from MGB rats but not RYGB rats. In rats, MGB led to greater protein malabsorption and energy loss than RYGB. This malabsorption was not compensated by intestinal overgrowth and increased expression of peptide transporters in the jejunum.



From: Cavin, J.-B., Voitellier, E., Cluzeaud, F., Kapel, N., Marmuse, J.-P., Chevallier, J.-M., Msika, S., Bado, A., Le Gall, M. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F3%2FG492%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Bovine colostrum improves neonatal growth, digestive function, and gut immunity relative to donor human milk and infant formula in preterm pigs

Mother's own milk is the optimal first diet for preterm infants, but donor human milk (DM) or infant formula (IF) is used when supply is limited. We hypothesized that a gradual introduction of bovine colostrum (BC) or DM improves gut maturation, relative to IF during the first 11 days after preterm birth. Preterm pigs were fed gradually advancing doses of BC, DM, or IF (3–15 ml·kg–1·3 h–1, n = 14–18) before measurements of gut structure, function, microbiology, and immunology. The BC pigs showed higher body growth, intestinal hexose uptake, and transit time and reduced diarrhea and gut permeability, relative to DM and IF pigs (P < 0.05). Relative to IF pigs, BC pigs also had lower density of mucosa-associated bacteria and of some putative pathogens in colon, together with higher intestinal villi, mucosal mass, brush-border enzyme activities, colonic short chain fatty acid levels, and bacterial diversity and an altered expression of immune-related genes (higher TNFα, IL17; lower IL8, TLR2, TFF, MUC1, MUC2) (all P < 0.05). Values in DM pigs were intermediate. Severe necrotizing enterocolitis (NEC) was observed in >50% of IF pigs, while only subclinical intestinal lesions were evident from DM and BC pigs. BC, and to some degree DM, are superior to preterm IF in stimulating gut maturation and body growth, using a gradual advancement of enteral feeding volume over the first 11 days after preterm birth in piglets. Whether the same is true in preterm infants remains to be tested.



From: Rasmussen, S. O., Martin, L., Ostergaard, M. V., Rudloff, S., Li, Y., Roggenbuck, M., Bering, S. B., Sangild, P. T. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F3%2FG480%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease

Muscularis propria throughout the entire gastrointestinal tract including the esophagus is comprised of circular and longitudinal muscle layers. Based on the studies conducted in the colon and the small intestine, for more than a century, it has been debated whether the two muscle layers contract synchronously or reciprocally during the ascending contraction and descending relaxation of the peristaltic reflex. Recent studies in the esophagus and colon prove that the two muscle layers indeed contract and relax together in almost perfect synchrony during ascending contraction and descending relaxation of the peristaltic reflex, respectively. Studies in patients with various types of esophageal motor disorders reveal temporal disassociation between the circular and longitudinal muscle layers. We suggest that the discoordination between the two muscle layers plays a role in the genesis of esophageal symptoms, i.e., dysphagia and esophageal pain. Certain pathologies may selectively target one and not the other muscle layer, e.g., in eosinophilic esophagitis there is a selective dysfunction of the longitudinal muscle layer. In achalasia esophagus, swallows are accompanied by the strong contraction of the longitudinal muscle without circular muscle contraction. The possibility that the discoordination between two muscle layers plays a role in the genesis of esophageal symptoms, i.e., dysphagia and esophageal pain are discussed. The purpose of this review is to summarize the regulation and dysregulation of peristalsis by the coordinated and discoordinated function of circular and longitudinal muscle layers in health and diseased states.



From: Mittal, R. K. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F3%2FG431%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have previously shown that the apical addition of serine proteases to intestinal epithelial cell lines causes a rapid and sustained increase in transepithelial electrical resistance (TER), but the mechanisms are unknown. We hypothesized that serine proteases increase barrier function through trafficking and insertion of tight junction proteins into the membrane, and this could enhance recovery of a disrupted monolayer after calcium switch or cytokine treatment. In the canine epithelial cell line, SCBN, we showed that matriptase, an endogenous serine protease, could potently increase TER. Using detergent solubility-based cell fractionation, we found that neither trypsin nor matriptase treatment changed levels of tight junction proteins at the membrane. In a fast calcium switch assay, serine proteases did not enhance the rate of recovery of the junction. In addition, serine proteases could not reverse barrier disruption induced by IFN and TNFα. We knocked down occludin in our cells using siRNA and found this prevented the serine protease-induced increase in TER. Using fluorescence recovery after photobleaching (FRAP), we found serine proteases induce a greater mobile fraction of occludin in the membrane. These data suggest that a functional tight junction is needed for serine proteases to have an effect on TER, and that occludin is a crucial tight junction protein in this mechanism.



From: Ronaghan, N. J., Shang, J., Iablokov, V., Zaheer, R., Colarusso, P., Turner, J. R., MacNaughton, W. K. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F311%2F3%2FG466%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Long noncoding RNAs: novel links to inflammatory bowel disease?



From: Edgington-Mitchell, L. E. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Ffull%2F311%2F3%2FG444%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Zika mosquitoes found in Florida

For the first time in the U.S., mosquitoes in South Florida have tested positive for the Zika virus. The Florida Department of Agriculture announced Thursday that three mosquito samples taken out of 19 from Miami Beach had the virus.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fzika-mosquitoes-found-in-florida%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Drugmakers may face more legal action over opioid epidemic

Group of state attorneys general nationwide have been discussing new ways they can pursue legal action against opioid manufacturers like Purdue Pharma, CBS News has learned

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Foxycontin-opioid-drug-makers-legal-action%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

New Version of RA Drug Enbrel: FAQ

research

The FDA cleared the way for what is hoped may be a more affordable version of the popular arthritis drug Enbrel. Tuesday the agency approved Erelzi (etanercept-szzs), a "biosimilar" to Enbrel.



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Frheumatoid-arthritis%2Fnews%2F20160901%2Ferelzi-biosimilar-enbrel-arthritis-faq%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

First Zika-carrying mosquitoes found in Miami Beach

Health officials confirmed the presence of the virus in trapped mosquitoes, including some at the Miami Beach Botanical Garden

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Ffirst-zika-carrying-mosquitoes-found-in-miami-beach%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Chickenpox Cases Down 85% With 2-Dose Vaccine: CDC

Kids 5 to 14 had the biggest drop in illness



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fchildren%2Fvaccines%2Fnews%2F20160901%2Fchickenpox-cases-down-85-percent-since-2-dose-vaccine-started-cdc%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

College depression: What parents need to know



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.mayoclinic.com%2Fhealthy-lifestyle%2Ftween-and-teen-health%2Fin-depth%2Fcollege-depression%2Fart-20048327&key=ddaed8f51db7bb1330a6f6de768a69b8

Do you live in one of America's fattest states?

New research ranks state-by-state obesity rates; see how your home state measures up

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Famericas-fattest-states-obesity-rates%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Mayo Clinic Medical School Expand to Arizona



From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DgcsnG4XvPl0&key=ddaed8f51db7bb1330a6f6de768a69b8

Making Mayo's Recipes: Smoky Frittata



From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3D_7r0OhJq1aA&key=ddaed8f51db7bb1330a6f6de768a69b8

ADA reveals 2016 Golden Apple Award recipients

The ADA announced Aug. 31 the recipients of the 28th annual Golden Apple Awards, which honor leaders, members and staff who have contributed to the success of dental society activities.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fseptember%2Fada-reveals-2016-golden-apple-award-recipients&key=ddaed8f51db7bb1330a6f6de768a69b8

Tobacco-related research abstract submissions due

Dental professionals who have research to share related to tobacco control are invited to submit their abstracts by Sept. 30 to organizers for the National Conference on Tobacco or Health.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fseptember%2Ftobacco-related-research-abstract-submissions-due&key=ddaed8f51db7bb1330a6f6de768a69b8

Newer Epilepsy Drugs May Be Safer During Pregnancy

Small British study says two drugs don't harm a child's mental development, but popular older one does



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fepilepsy%2Fnews%2F20160901%2Fnewer-epilepsy-drugs-may-be-safer-during-pregnancy%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Zika Linked to Spikes in Temporary Paralysis Cases

Multi-country analysis documents increases in Guillain-Barre syndrome when virus is spreading



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fnews%2F20160901%2Fstrong-link-emerges-between-zika-spikes-in-temporary-paralysis-cases%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Jim’s Mayo Experience: Sarcoidosis of the Heart



From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DIzFlvWDNWK8&key=ddaed8f51db7bb1330a6f6de768a69b8

Ingestion of Wheat Protein Increases In Vivo Muscle Protein Synthesis Rates in Healthy Older Men in a Randomized Trial [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: To our knowledge the efficacy of soy-dairy protein blend (PB) supplementation with resistance exercise training (RET) has not been evaluated in a longitudinal study.

Objective: Our aim was to determine the effect of PB supplementation during RET on muscle adaptation.

Methods: In this double-blind randomized clinical trial, healthy young men [18–30 y; BMI (in kg/m2): 25 ± 0.5] participated in supervised whole-body RET at 60–80% 1-repetition maximum (1-RM) for 3 d/wk for 12 wk with random assignment to daily receive 22 g PB (n = 23), whey protein (WP) isolate (n = 22), or an isocaloric maltodextrin (carbohydrate) placebo [(MDP) n = 23]. Serum testosterone, muscle strength, thigh muscle thickness (MT), myofiber cross-sectional area (mCSA), and lean body mass (LBM) were assessed before and after 6 and 12 wk of RET.

Results: All treatments increased LBM (P < 0.001). ANCOVA did not identify an overall treatment effect at 12 wk (P = 0.11). There tended to be a greater change in LBM from baseline to 12 wk in the PB group than in the MDP group (0.92 kg; 95% CI: –0.12, 1.95 kg; P = 0.09); however, changes in the WP and MDP groups did not differ. Pooling data from combined PB and WP treatments showed a trend for greater change in LBM from baseline to 12 wk compared with MDP treatment (0.69 kg; 95% CI: –0.08, 1.46 kg; P = 0.08). Muscle strength, mCSA, and MT increased (P < 0.05) similarly for all treatments and were not different (P > 0.10) between treatments. Testosterone was not altered.

Conclusions: PB supplementation during 3 mo of RET tended to slightly enhance gains in whole-body and arm LBM, but not leg muscle mass, compared with RET without protein supplementation. Although protein supplementation minimally enhanced gains in LBM of healthy young men, there was no enhancement of gains in strength. This trial was registered at clinicaltrials.gov as NCT01749189.



From: Reidy, P. T., Borack, M. S., Markofski, M. M., Dickinson, J. M., Deer, R. R., Husaini, S. H., Walker, D. K., Igbinigie, S., Robertson, S. M., Cope, M. B., Mukherjea, R., Hall-Porter, J. M., Jennings, K., Volpi, E., Rasmussen, B. B. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F9%2F1660%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Vitamin A Supplementation Increases the Uptake of Chylomicron Retinyl Esters into the Brain of Neonatal Rats Raised under Vitamin A-Marginal Conditions [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: The most rapid phase of brain development occurs during the neonatal period. Vitamin A (VA; retinol) is critical for many aspects of this process, including neurogenesis, synaptic plasticity, learning, and memory formation. However, the metabolism of retinol in the neonatal brain has not been extensively explored.

Objective: We examined the uptake of VA into the brain in neonatal rats raised under VA-marginal conditions (control group) and assessed the effect of VA supplementation on the uptake of VA into the brain.

Methods: Sprague-Dawley neonatal rats (n = 104) nursed by mothers fed a VA-marginal diet were randomly assigned and treated on postnatal day 4 with an oral dose of either VA (6 μg retinyl palmitate/g body weight) or canola oil as the control, both of which contained 1.8 μCi [3H]retinol. Pups (n = 4/group at a time) were killed at 13 sampling times from 30 min to 24 d after dosing. The uptake of total retinol, chylomicron-associated retinyl esters (REs), and retinol bound to retinol-binding protein (RBP) was estimated with the use of WinSAAM version 3.0.8.

Results: Total retinol mass in the brain was closely dependent on its mass in plasma over time (r = 0.91; P < 0.001). The uptake of retinol into the brain involved both postprandial chylomicrons and RBP, with RBP delivering most of the retinol in the control group [0.27 nmol/d (RBP) compared with 0.01 nmol/d (chylomicrons)]. VA supplementation increased the fractional uptake of chylomicron REs from 0.3% to 1.2% of plasma pool/d, decreased that of RBP retinol from 0.5% to 0.2% of plasma pool/d, and increased the transfer rate of chylomicron REs from nearly zero to 0.7 nmol/d, causing a day-long elevation in the brain mass of total retinol.

Conclusion: Postprandial chylomicrons may be a primary mechanism for delivering a recently ingested large dose of VA to the brain of neonatal rats raised under VA-marginal conditions.



From: Hodges, J. K., Tan, L., Green, M. H., Ross, A. C. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F9%2F1677%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Serum Zinc Is a Major Predictor of Anemia and Mediates the Effect of Selenium on Hemoglobin in School-Aged Children in a Nationally Representative Survey in New Zealand [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: Zinc, selenium, and vitamin D status of New Zealand (NZ) school-aged children was examined in a national survey in 2002. To our knowledge, however, the role of these micronutrients as predictors of hemoglobin has not been explored despite plausible mechanisms for such relations.

Objective: We examined the relations of iron, zinc, selenium, and vitamin D status with hemoglobin and anemia in children of New Zealand European and other (NZEO) ethnicity enrolled in the 2002 Children’s Nutrition Survey and explored whether zinc mediated the relation between selenium and hemoglobin.

Methods: Multivariate regression was performed to examine the relations of serum micronutrient biomarkers, acute inflammation, socioeconomic status, and body mass index (BMI) with hemoglobin and anemia of NZEO children aged 5–15 y (n = 503). A mediation analysis also investigated direct and indirect (through zinc) relations between selenium and hemoglobin.

Results: In total, 4.6% of the children were anemic, 3.2% had depleted iron stores, and none had iron deficiency anemia. The prevalence of low serum zinc (<8.7–10.1 μmol/L depending on age and sex), selenium (<0.82 μmol/L), and 25-hydroxyvitamin D (<50 nmol/L) was 14.1%, 22.9%, and 48.5%, respectively. Major predictors of hemoglobin were serum zinc, age, and BMI-for-age z score (P < 0.001); log ferritin and being female were also statistically significant (P < 0.05). Selenium had an indirect effect that was mediated by zinc, with a significant effect of selenium on zinc (P = 0.002) and zinc on hemoglobin (P < 0.001). Zinc was the only variable associated with anemia risk (OR: 5.49; 95% CI: 1.95, 15.46).

Conclusions: Low serum zinc was an independent risk factor for anemia in NZEO school-aged children and mediated the effect of low selenium on hemoglobin. These findings emphasize the importance of considering multiple micronutrient deficiencies in addition to iron when interpreting anemia and of appreciating the mechanistic interactions that underlie these associations.



From: Houghton, L. A., Parnell, W. R., Thomson, C. D., Green, T. J., Gibson, R. S. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F9%2F1670%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Dr. Jamie Bakkum-Gamez discusses gonorrhea



From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DofEWaieFrX8&key=ddaed8f51db7bb1330a6f6de768a69b8

Mayo Clinic Minute: Sun protection is for all seasons



From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DqcyEoDgUFqg&key=ddaed8f51db7bb1330a6f6de768a69b8

College depression: What parents need to know



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.mayoclinic.org%2Fhealthy-lifestyle%2Ftween-and-teen-health%2Fin-depth%2Fcollege-depression%2Fart-20048327&key=ddaed8f51db7bb1330a6f6de768a69b8

Some Entenmann's Little Bites snacks recalled

Popular snacks may have bits of plastic that could be hazardous

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fentenmanns-recall-plastic-found-in-some-little-bites-snacks%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

FDA warns mixing these common drugs can be deadly

A strong new FDA warning will be placed on close to 400 products to warn of dangerous drug combinations

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fmixing-opioids-oxycodone-and-popular-sedatives-xanax-may-be-deadly%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

College depression: What parents need to know



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.mayoclinic.com%2Fhealthy-lifestyle%2Ftween-and-teen-health%2Fin-depth%2Fcollege-depression%2Fart-20048327&key=ddaed8f51db7bb1330a6f6de768a69b8

Patients May Lose Beneficial Gut Bacteria in ICU

Increased levels of harmful bacteria boost the risk for hospital-acquired infections, researchers say



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fdigestive-disorders%2Fnews%2F20160831%2Fpatients-may-quickly-lose-beneficial-gut-bacteria-in-the-icu%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

New Drug Shows Promise Against Alzheimer's

New Drug Shows Promise Against Alzheimer's



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Falzheimers%2Fnews%2F20160831%2Fdrug-alzheimers%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

More U.S. Adults Using Marijuana Than Ever

Daily use nearly doubled between 2002 and 2014, study finds



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fmental-health%2Faddiction%2Fnews%2F20160831%2Fmore-us-adults-using-marijuana-than-ever%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

College depression: What parents need to know



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.mayoclinic.org%2Fhealthy-lifestyle%2Ftween-and-teen-health%2Fin-depth%2Fcollege-depression%2Fart-20048327&key=ddaed8f51db7bb1330a6f6de768a69b8

FDA: Opioids Plus Sedatives Pose Fatal OD Risk

These drugs will now carry 'boxed warning' detailing the threat



From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fmental-health%2Faddiction%2Fnews%2F20160831%2Ffda-opioids-plus-sedatives-pose-fatal-od-risk%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

WHO: Research to reduce Chagas disease and dengue transmission



From: World Health Organization http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3D82oygsLIvE4&key=ddaed8f51db7bb1330a6f6de768a69b8

Diabetes Advocacy With a Crown

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“And the winner is . . .”

1999_NicoleJohnson

Nicole Johnson, Miss America 1999

You’ve just been crowned Miss America. Imagine hearing these words in front of thousands of people in the audience and millions watching at home. Now you will be on the road for more than 360 days out of the year supporting your platform. Your cause: Diabetes Education and Awareness.

While winning the title of Miss America can only happen to one person each year, many state titleholders promote their platform locally. But for those who do win the title of Miss America, it’s a once-in-a-lifetime experience. And it’s made even more special if the contestant has a close connection to diabetes—or even lives with it herself.

Nicole Johnson, PhD, was the first contestant with type 1 diabetes to win the Miss America competition in 1999. She was also the first to visibly wear her insulin pump on the runway.

“Becoming Miss America allowed me to have a voice and a platform that were immediately legitimate,” says Nicole. “At 24 it was incredible to go from college student to national advocate and spokesperson in a moment.”

The title of Miss America was a beginning, but certainly not an ending, for Nicole. Since she won the title, she has expanded her education and skills to help more people with diabetes than she ever could have imagined: “Today, I conduct diabetes behavioral research, run national programs and train others. Miss America was an incredible blessing—and something I continue to learn from even today.”

Nicole set the stage for many other contestants with a diabetes connection. In 2014, Sierra Sandison also chose to wear her insulin pump during the swimsuit portion of the Miss Idaho competition and won the state title. Her Facebook photo quickly went viral and inspired many young women to share their own pump photos with the #showmeyourpump hashtag.

Daja Dial, Miss South Carolina 2015, made it her mission to educate people about diabetes, in honor of her older brother. You can read more about her connection to diabetes via Diabetes Forecast magazine. Dial placed in the top 7 during last year’s event.

Age doesn’t limit your capacity to advocate. At the age of 17, Emily Brewer, Miss Arkansas’ Outstanding Teen 2016, has supported American Diabetes Association® events and advocacy programs at the local and state level. She recently won the Teens in Action award for her platform, Winning Against Diabetes, during the Miss America Outstanding Teen competition.

“I chose my platform because my uncle passed away at 23 due to complications with type 1 diabetes,” says Emily. “My great-aunt has type 2 diabetes, and both types are very common in my family. It’s something that I’ve seen firsthand and am very concerned and passionate about.”

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Caroline Carter, Miss New Hampshire 2016

This year, Caroline Carter, Miss New Hampshire 2016, will compete on the national stage and attempt to follow Nicole Johnson’s footsteps. Carter was diagnosed with type 1 diabetes at the age of 12. She recently wore her insulin pump and continuous glucose monitor during the swimsuit portion of the Miss New Hampshire competition. “The diabetes community went wild,” Caroline says about winning her state’s title. “Ever since April, even to today, I have been getting pictures of children proudly showing their diabetes supplies.”

Caroline’s personal platform is “1, 2, We: Diabetes Advocacy.” During her year of service, she hopes to spread diabetes awareness and education, and break some of the stereotypes surrounding the disease.

“[Winning the Miss America title] would be such an amazing opportunity for me!” says Caroline. “I would have the ability to meet thousands of people with diabetes along my journey, and as Miss America, I would be able to educate not only my community, but also the nation on the dangers of this disease and ways to live with it.”

Whether you’re in front of a national audience or speaking locally with government officials, advocacy is an important part of the Association’s work. Thanks to advocates like Nicole Johnson and others across the country, we can transform the lives of all people with diabetes.

For more information on how to become a diabetes advocate, visit diabetes.org/advocate.



From: American Diabetes Association http://redirect.viglink.com?u=http%3A%2F%2Fdiabetesstopshere.org%2F2016%2F09%2F01%2Fdiabetes-advocacy-with-a-crown%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

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