Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice

The pathogenesis of necrotizing enterocolitis (NEC), a common gastrointestinal disease affecting premature infants, remains poorly understood. We previously found that intestinal VEGF-A expression is decreased in human NEC samples and in a neonatal mouse NEC model prior to detectable histological injury. Therefore, we hypothesized that lack of VEGF receptor 2 (VEGFR2) signaling facilitates neonatal intestinal injury by impairing intestinal microvasculature development. Here, we found that intestinal VEGF-A and its receptor, VEGFR2, were highly expressed at the end of fetal life and significantly decreased after birth in mice. Furthermore, selective inhibition of VEGFR2 kinase activity and exposure to a neonatal NEC protocol significantly decreased the density of the intestinal microvascular network, which was further reduced when both interventions were provided together. Furthermore, VEGFR2 inhibition resulted in greater mortality and incidence of severe injury in pups submitted to the NEC model. The percentage of lamina propria endothelial cells was decreased during NEC induction, and further decreased when VEGFR2 signaling was inhibited. This was associated with decreased endothelial cell proliferation rather than apoptosis. In conclusion, we found that VEGF-A and VEGFR2 proteins are highly expressed in the intestine before birth, and are significantly downregulated in the immediate neonatal period. Furthermore, VEGFR2 signaling is necessary to maintain the integrity of the intestinal mucosal microvasculature during the postnatal period and lack of VEGFR2 signaling predisposes to NEC in neonatal mice.

From: Yan, X., Managlia, E., Liu, S. X., Tan, X.-D., Wang, X., Marek, C., De Plaen, I. G. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F310%2F9%2FG716%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Selective portal vein injection for the design of syngeneic models of liver malignancy

Liver metastases are the most frequent cause of death due to colorectal cancer (CRC). Syngeneic orthotopic animal models, based on the grafting of cancer cells or tissue in host liver, are efficient systems for studying liver tumors and their (patho)physiological environment. Here we describe selective portal vein injection as a novel tool to generate syngeneic orthotopic models of liver tumors that avoid most of the weaknesses of existing syngeneic models. By combining portal vein injection of cancer cells with the selective clamping of distal liver lobes, tumor growth is limited to specific lobes. When applied on MC-38 CRC cells and their mouse host C57BL6, selective portal vein injection leads with 100% penetrance to MRI-detectable tumors within 1 wk, followed by a steady growth until the time of death (survival ~7 wk) in the absence of extrahepatic disease. Similar results were obtained using CT-26 cells and their syngeneic Balb/c hosts. As a proof of principle, lobe-restricted liver tumors were also generated using Hepa1-6 (C57BL6-syngeneic) and TIB-75 (Balb/c-syngeneic) hepatocellular cancer cells, demonstrating the general applicability of selective portal vein injection for the induction of malignant liver tumors. Selective portal vein injection is technically straightforward, enables liver invasion via anatomical routes, preserves liver function, and provides unaffected liver tissue. The tumor models are reproducible and highly penetrant, with survival mainly dependent on the growth of lobe-restricted liver malignancy. These models enable biological studies and preclinical testing within short periods of time.

From: Limani, P., Borgeaud, N., Linecker, M., Tschuor, C., Kachaylo, E., Schlegel, A., Jang, J.-H., Ungethüm, U., Montani, M., Graf, R., Humar, B., Clavien, P.-A. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F310%2F9%2FG682%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

"Asian tiger" mosquito could carry Zika virus to more U.S. states

There are new fears about the spread of the mosquito-borne Zika virus

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fasian-tiger-mosquito-could-carry-zika-virus-to-more-u-s-states%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

New Zika alert: Beware the Asian tiger mosquito

CDC says Zika virus has been found in a second mosquito, Aedes albopictus, which is found in more states of the U.S.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fzika-virus-may-be-carried-farther-north-than-first-thought%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

CDC investigating after 97 fall sick on Disney cruise ship

Stomach bug outbreak aboard the Disney Wonder cruise ship impacted both passengers and crew members, CDC says

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fcdc-investigating-after-97-fall-sick-on-disney-cruise-ship%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Chronic insomnia? Why pills may not be the answer

Before you look to medication to get some much-needed shut-eye, doctors say you should try this first

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fchronic-insomnia-why-pills-may-not-be-the-answer%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

HS Football Players and Symptoms After Concussion

Meanwhile, youth league players most likely to return to field less than 24 hours after head injury

From: http://redirect.viglink.com?u=http%3A%2F%2Fteens.webmd.com%2Fnews%2F20160502%2Fhigh-school-football-players-suffer-more-symptoms-after-concussion-study%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Using a Computer, Social Activities Tied to Reduced Risk of Memory Decline

From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DnKRs9-RphnE&key=ddaed8f51db7bb1330a6f6de768a69b8

Drinking Water Week highlights invaluable resource

The vital role tap water plays in daily life is highlighted May 1-7 during American Water Works Association's Drinking Water Week.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fmay%2Fdrinking-water-week-highlights-invaluable-resource&key=ddaed8f51db7bb1330a6f6de768a69b8

Dental school apologizes over kids' laughing gas exposure

School said 124 patients who underwent procedures at a pediatric dentistry clinic face an "extremely small risk" of long-term health effects

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fiowa-dental-school-apologizes-kids-laughing-gas-exposure%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Non-Obese Report Better Mood, Libido After Dieting

Calorie cutters said their sleep and relationships improved, too

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fdiet%2F20160502%2Feven-non-obese-report-better-mood-sex-drive-after-dieting%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Could Talk Therapy Ease Chemo Memory Issues?

Researchers suggest their approach could improve survivors' quality of life

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fcancer%2Fnews%2F20160502%2Fcould-talk-therapy-ease-chemo-related-memory-issues%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

USDA Announces $6 Million in Available Funding for Antimicrobial Resistance Research

WASHINGTON, May 2, 2016 - The U.S. Department of Agriculture (USDA) today announced the availability of $6 million to fund research to address antimicrobial resistance (AMR). This funding is available through the Agriculture and Food Research Initiative (AFRI), authorized by the 2014 Farm Bill, and administered by USDA's National Institute of Food and Agriculture (NIFA).

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.usda.gov%2Fwps%2Fportal%2Fusda%2Fusdahome%3Fcontentid%3D2016%2F05%2F0100.xml%26amp%3Bcontentidonly%3Dtrue&key=ddaed8f51db7bb1330a6f6de768a69b8

More U.S. kids have chronic health problems

Children living in poverty are being hit hardest, researchers report

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fmore-u-s-kids-have-chronic-health-problems-study%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Thai noodles? Some nursing homes cater to personal tastes

Some nursing homes are creating menus that reflect religious, cultural and nutritional needs, and abandoning rigid hospital-style food

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fthai-noodles-anyone-some-nursing-homes-cater-to-personal-tastes%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Vedolizumab Safe for Inflammatory Bowel Disease – IBD in the News

From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3D0jla3uQoO1E&key=ddaed8f51db7bb1330a6f6de768a69b8

Ruminal Infusions of Cobalt EDTA Modify Milk Fatty Acid Composition via Decreases in Fatty Acid Desaturation and Altered Gene Expression in the Mammary Gland of Lactating Cows [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: Intravenous or ruminal infusion of lithium salt of cobalt EDTA (Co-EDTA) or cobalt-acetate alters milk fat composition in cattle, but the mechanisms involved are not known.

Objective: The present study evaluated the effect of ruminal Co-EDTA infusion on milk FA composition, mammary lipid metabolism, and mammary lipogenic gene expression.

Methods: For the experiment, 4 cows in midlactation and fitted with rumen cannulae were used in a 4 x 4 Latin square with 28-d periods. Co-EDTA was administered in the rumen to supply 0, 1.5, 3.0, or 4.5 g Co/d over an 18-d interval with a 10-d washout between experimental periods. Milk production was recorded daily, and milk FA composition was determined on alternate days. Mammary tissue was biopsied on day 16, and arteriovenous differences of circulating lipid fractions and FA uptake across the mammary gland were measured on day 18.

Results: Co-EDTA had no effect on intake, proportions of rumen volatile FA, or milk production but caused dose-dependent changes in milk FA composition. Alterations in milk fat composition were evident within 3 d of infusion and characterized by linear or quadratic decreases (P < 0.05) in FAs containing a cis-9 double bond, an increase in 4:0 and 16:0, and linear decreases in milk 8:0, 10:0, 12:0, and 14:0 concentrations. Co-EDTA progressively decreased (P < 0.05) the stearoyl-CoA desaturase (SCD)-catalyzed desaturation of FAs in the mammary gland by up to 72% but had no effect on mammary SCD1 mRNA or SCD protein abundance. Changes in milk FA composition were accompanied by altered expression of specific genes involved in de novo FA and triacylglycerol synthesis.

Conclusion: Ruminal infusion of Co-EDTA alters milk FA composition in cattle via a mechanism that involves decreases in the desaturation of FAs synthesized de novo or extracted from blood and alterations in mammary lipogenic gene expression, without affecting milk fat yield.

From: Leskinen, H., Viitala, S., Mutikainen, M., Kairenius, P., Tapio, I., Taponen, J., Bernard, L., Vilkki, J., Shingfield, K. J. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F5%2F976%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Nitrate-Rich Vegetables Increase Plasma Nitrate and Nitrite Concentrations and Lower Blood Pressure in Healthy Adults [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: Dietary nitrate is receiving increased attention due to its reported ergogenic and cardioprotective properties. The extent to which ingestion of various nitrate-rich vegetables increases postprandial plasma nitrate and nitrite concentrations and lowers blood pressure is currently unknown.

Objective: We aimed to assess the impact of ingesting different nitrate-rich vegetables on subsequent plasma nitrate and nitrite concentrations and resting blood pressure in healthy normotensive individuals.

Methods: With the use of a semirandomized crossover design, 11 men and 7 women [mean ± SEM age: 28 ± 1 y; mean ± SEM body mass index (BMI, in kg/m²): 23 ± 1; exercise: 1–10 h/wk] ingested 4 different beverages, each containing 800 mg (~12.9 mmol) nitrate: sodium nitrate (NaNO₃), concentrated beetroot juice, a rocket salad beverage, and a spinach beverage. Plasma nitrate and nitrite concentrations and blood pressure were determined before and up to 300 min after beverage ingestion. Data were analyzed using repeated-measures ANOVA.

Results: Plasma nitrate and nitrite concentrations increased after ingestion of all 4 beverages (P < 0.001). Peak plasma nitrate concentrations were similar for all treatments (all values presented as means ± SEMs: NaNO₃: 583 ± 29 μmol/L; beetroot juice: 597 ± 23 μmol/L; rocket salad beverage: 584 ± 24 μmol/L; spinach beverage: 584 ± 23 μmol/L). Peak plasma nitrite concentrations were different between treatments (NaNO₃: 580 ± 58 nmol/L; beetroot juice: 557 ± 57 nmol/L; rocket salad beverage: 643 ± 63 nmol/L; spinach beverage: 980 ± 160 nmol/L; P = 0.016). When compared with baseline, systolic blood pressure declined 150 min after ingestion of beetroot juice (from 118 ± 2 to 113 ± 2 mm Hg; P < 0.001) and rocket salad beverage (from 122 ± 3 to 116 ± 2 mm Hg; P = 0.007) and 300 min after ingestion of spinach beverage (from 118 ± 2 to 111 ± 3 mm Hg; P < 0.001), but did not change with NaNO₃. Diastolic blood pressure declined 150 min after ingestion of all beverages (P < 0.05) and remained lower at 300 min after ingestion of rocket salad (P = 0.045) and spinach (P = 0.001) beverages.

Conclusions: Ingestion of nitrate-rich beetroot juice, rocket salad beverage, and spinach beverage effectively increases plasma nitrate and nitrite concentrations and lowers blood pressure to a greater extent than sodium nitrate. These findings show that nitrate-rich vegetables can be used as dietary nitrate supplements. This trial was registered at clinicaltrials.gov as NCT02271633.

From: Jonvik, K. L., Nyakayiru, J., Pinckaers, P. J., Senden, J. M., van Loon, L. J., Verdijk, L. B. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F5%2F986%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: Glycine traditionally is classified as a nutritionally nonessential amino acid in humans and animals. Because of its abundance in the body and its extensive use via multiple pathways, requirements for glycine are particularly high in neonates. Our recent studies show that dietary glycine supplementation is needed for optimal intestinal development in piglets. Importantly, reduced concentrations of glycine in the lumen of the small intestine are associated with gut dysfunction in low-birth-weight piglets. However, the mechanisms responsible for the beneficial effects of glycine on the intestinal mucosal barrier are largely unknown.

Objective: This study tested the hypothesis that glycine may regulate the expression and distribution of tight junction (TJ) proteins, thereby contributing to intestinal mucosal barrier function.

Methods: Enterocytes isolated from the jejunum of a healthy newborn pig were propagated to establish a stable cell line. The cells were cultured with 0.05 mmol glycine/L (control; concentration in the small intestinal lumen of low-birth-weight piglets) or 0.25 or 1.0 mmol glycine/L for the indicated periods of time. Epithelial barrier integrity and expression and localization of TJ proteins were analyzed by using monolayer transepithelial electrical resistance (TEER) and paracellular permeability, Western blot, and immunofluorescence imaging.

Results: Compared with controls, cells cultured with 0.25 or 1.0 mmol glycine/L increased TEER (P < 0.05) by 46–53% and 80–111%, respectively, at 60–72 h. Correspondingly, paracellular permeability was reduced (P < 0.05) by 6–21% and 18–27% for 0.25 or 1.0 mmol glycine/L treatment, respectively, at 36–72 h. Compared with controls, protein abundances for claudin-3, claudin-7, and zonula occludens (ZO) 3 were enhanced (25–33%, P < 0.05) by 0.25 and 1.0 mmol glycine/L at 8 h, whereas those for occludin, claudin-1, claudin-4, and ZO-2 were not affected. Compared with controls, 1.0 mmol glycine/L reduced the protein abundance of ZO-1 by 20% at 8 h (P < 0.05), but 0.25 mmol glycine/L had no effect. A glycine concentration of 0.25 mmol/L sustained the localization of claudin-7 and ZO-3 to the interface between enterocytes. Interestingly, 1 mmol glycine/L promoted the distribution of claudin-4 and claudin-7 to the cytosol and nucleus, and the localization of ZO-3 to the plasma membranes, while decreasing the distribution of ZO-1 at cell–cell contact sites, compared with control cells.

Conclusion: Physiologic concentrations of glycine support intestinal mucosal barrier function by regulating the abundance and distribution of claudin-7 and ZO-3 in enterocytes. Supplementation with glycine may provide an effective nutritional strategy to improve intestinal integrity in piglets.

From: Li, W., Sun, K., Ji, Y., Wu, Z., Wang, W., Dai, Z., Wu, G. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F5%2F964%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

In Rwandese Women with Low Iron Status, Iron Absorption from Low-Phytic Acid Beans and Biofortified Beans Is Comparable, but Low-Phytic Acid Beans Cause Adverse Gastrointestinal Symptoms [Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions]

Background: Phytic acid (PA) is a major inhibitor of iron bioavailability from beans, and high PA concentrations might limit the positive effect of biofortified beans (BBs) on iron status. Low-phytic acid (lpa) bean varieties could increase iron bioavailability.

Objective: We set out to test whether lpa beans provide more bioavailable iron than a BB variety when served as part of a composite meal in a bean-consuming population with low iron status.

Methods: Dietary iron absorption from lpa, iron-biofortified, and control beans (CBs) (regular iron and PA concentrations) was compared in 25 nonpregnant young women with low iron status with the use of a multiple-meal crossover design. Iron absorption was measured with stable iron isotopes.

Results: PA concentration in lpa beans was ~10% of BBs and CBs, and iron concentration in BBs was ~2- and 1.5-fold compared with CBs and lpa beans, respectively. Fractional iron absorption from lpa beans [8.6% (95% CI: 4.8%, 15.5%)], BBs [7.3% (95% CI: 4.0%, 13.4%)], and CBs [8.0% (95% CI: 4.4%, 14.6%)] did not significantly differ. The total amount of iron absorbed from lpa beans and BBs was 421 μg (95% CI: 234, 756 μg) and 431 μg (95% CI: 237, 786 μg), respectively, and did not significantly differ, but was >50% higher (P < 0.005) than from CBs (278 μg; 95% CI: 150, 499 μg). In our trial, the lpa beans were hard to cook, and their consumption caused transient adverse digestive side effects in ~95% of participants. Gel electrophoresis analysis showed phytohemagglutinin L (PHA-L) residues in cooked lpa beans.

Conclusion: BBs and lpa beans provided more bioavailable iron than control beans and could reduce dietary iron deficiency. Digestive side effects of lpa beans were likely caused by PHA-L, but it is unclear to what extent the associated digestive problems reduced iron bioavailability. This trial was registered at clinicaltrials.gov as NCT02215278.

From: Petry, N., Rohner, F., Gahutu, J. B., Campion, B., Boy, E., Tugirimana, P. L., Zimmerman, M. B., Zwahlen, C., Wirth, J. P., Moretti, D. http://redirect.viglink.com?u=http%3A%2F%2Fjn.nutrition.org%2Fcgi%2Fcontent%2Fshort%2F146%2F5%2F970%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Mayo Clinic Minute: Snuffing Out Smokeless Tobacco

From: Mayo Clinic http://redirect.viglink.com?u=http%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DHxBvy0AY3sc&key=ddaed8f51db7bb1330a6f6de768a69b8

High blood pressure: Why me?

“I go to the gym, and I never add salt. So why do I have high blood pressure?” Despite its astonishing prevalence of one in three Americans, many people struggle with the diagnosis of high blood pressure, or hypertension. It’s worth exploring why, because being an active participant in your care is crucial for optimal blood pressure control.

Certain features make any diagnosis easier to accept:

• First, people are more likely to accept a diagnosis if they have symptoms. A person with cough and fever will believe a diagnosis of pneumonia. But someone who feels fine would not.
• Next, people more readily accept a diagnosis if it is not serious. Most people won’t question the diagnosis of athlete’s foot, because creams can cure it. Diagnoses that carry worse prognoses are usually harder to receive.
• Finally, people accept a diagnosis better when they understand its cause. Some diseases have clear causes: Down syndrome and older maternal age, HIV infection and contaminated needles. A smoker who learns he has lung cancer may not be shocked. But non-smokers who receive this diagnosis usually ask, “Why me?”

People diagnosed with hypertension are often baffled, and many ask, “Why me?” This doubt makes sense, in light of the principles above. Symptoms make a diagnosis more real. But unlike many other illnesses, hypertension rarely causes symptoms. In fact, it is ominously called the “silent killer.” Some people develop headaches when their blood pressure rises into dangerous territory, but in others, hypertension can go undetected until it causes a lethal heart attack. Fortunately, it is easy and painless to measure blood pressure.

When doctors deliver the diagnosis of hypertension, they package it with serious complications. These include heart attack, kidney failure, and stroke. Doctors discuss risks to motivate their patients, but sometimes end up creating fear instead. And fear can lead to denial. Is hypertension serious? Yes, if left untreated. But when blood pressure is controlled, the risks are greatly reduced. The important message is that treating hypertension can prevent severe complications and add dramatically to life expectancy.

Last, knowing the cause of disease is helpful. In reality we rarely find just one cause for anyone’s hypertension. There are almost always multiple factors at work. Some causes can’t be prevented, like genetics and age. High blood pressure often runs in families. Genetic risk is complex, probably resulting from a combination of harmful mutations in risk genes and silencing of protective genes. There is nothing we can do to change our genetics, just as we can’t stop aging. With aging comes a universal increase in systolic blood pressure (the top number) and in the risk for heart disease. On the other hand, tackling modifiable risk factors for high blood pressure, for example, losing weight and getting more exercise, often produces great benefits.

Your odds of developing high blood pressure are pretty good

To answer the question “Why me?” it helps to know the data. The Framingham Heart Study followed a subset of 1,300 participants ages 55 to 65 who did not have hypertension at baseline. Their remarkable finding: the lifetime risk of developing hypertension was 90%. So even if you haven’t developed high blood pressure by middle age, chances are nine out of ten that you will at some point. This number is most likely so high because more of us are overweight and are living longer.

So instead of being surprised if you are diagnosed with hypertension, it is actually more logical to be amazed if you never develop it. On an optimistic note, we have seen a decline in the frequency of severe hypertension. We owe this fall to better treatment. So if you learn you have high blood pressure, the most important response is to accept the diagnosis. Hypertension can’t remedy itself; your commitment is the first step toward great blood pressure control.

Watch this video for more commentary on getting a high blood pressure diagnosis:

Related Post:

• Prehypertension increases stroke risk
• Update on the SPRINT trial: Preliminary results pan out
• New guidelines published for managing high blood pressure
• High blood pressure in midlife linked to later decline in…
• Checking blood pressure at home pays off

The post High blood pressure: Why me? appeared first on Harvard Health Blog.

From: Naomi D. L. Fisher, MD http://redirect.viglink.com?u=http%3A%2F%2Fwww.health.harvard.edu%2Fblog%2Fhigh-blood-pressure-why-me-201605029288&key=ddaed8f51db7bb1330a6f6de768a69b8

Keeping in sync at ADA annual meeting

Drs. John Mott and James Maslowski are partners in a practice in West Springfield, Massachusetts, and they both attended ADA 2015 – America’s Dental Meeting in Washington, D.C.


From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fmay%2Fkeeping-in-sync-at-ada-annual-meeting&key=ddaed8f51db7bb1330a6f6de768a69b8

More U.S. Kids Have Chronic Health Problems: Study

Low-income children are experiencing the biggest increases, researchers report

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fchildren%2Fnews%2F20160430%2Fmore-us-kids-have-chronic-health-problems-study%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Pesticide Spraying Tied to Higher Autism Rates?

But researcher said finding doesn't prove cause-and-effect connection

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fbrain%2Fautism%2Fnews%2F20160430%2Fstudy-suggests-aerial-pesticide-spraying-tied-to-higher-autism-rates%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Seniors' Worsening Depression May Predict Dementia

Study suggests a common underlying cause in some, but not all, cases

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fhealthy-aging%2Fnews%2F20160429%2Fseniors-worsening-depression-may-sometimes-predict-dementia%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Playground-related brain injuries on the rise

New data shows monkey bars, playground gyms, and swings were cited most often in connection with head injuries

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fplayground-related-injuries-on-the-rise%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

CE available for webinars on tobacco

The ADA is offering two webinar opportunities for continuing education about tobacco.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fmay%2Fce-available-for-webinars-on-tobacco&key=ddaed8f51db7bb1330a6f6de768a69b8

Just the Facts - May 2

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.ada.org%2Fen%2Fpublications%2Fada-news%2F2016-archive%2Fmay%2Fjust-the-facts-may-2&key=ddaed8f51db7bb1330a6f6de768a69b8