Tuesday, December 13, 2016

Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity

Strategies for prevention and treatment of nonalcoholic steatohepatitis remain to be established. We evaluated the effect of glycine on metabolic steatohepatitis in genetically obese, diabetic KK-Ay mice. Male KK-Ay mice were fed a diet containing 5% glycine for 4 wk, and liver pathology was evaluated. Hepatic mRNA levels for lipid-regulating molecules, cytokines/chemokines, and macrophage M1/M2 markers were determined by real-time RT-PCR. Hepatic expression of natural killer (NK) T cells was analyzed by flow cytometry. Body weight gain was significantly blunted and development of hepatic steatosis and inflammatory infiltration were remarkably prevented in mice fed the glycine-containing diet compared with controls. Indeed, hepatic induction levels of molecules related to lipogenesis were largely blunted in the glycine diet-fed mice. Elevations of hepatic mRNA levels for TNFα and chemokine (C-C motif) ligand 2 were also remarkably blunted in the glycine diet-fed mice. Furthermore, suppression of hepatic NK T cells was reversed in glycine diet-fed KK-Ay mice, and basal hepatic expression levels of NK T cell-derived cytokines, such as IL-4 and IL-13, were increased. Moreover, hepatic mRNA levels of arginase-1, a marker of macrophage M2 transformation, were significantly increased in glycine diet-fed mice. In addition, dietary glycine improved glucose tolerance and hyperinsulinemia in KK-Ay mice. These observations clearly indicate that glycine prevents maturity-onset obesity and metabolic steatohepatitis in genetically diabetic KK-Ay mice. The underlying mechanisms most likely include normalization of hepatic innate immune responses involving NK T cells and M2 transformation of Kupffer cells. It is proposed that glycine is a promising immunonutrient for prevention and treatment of metabolic syndrome-related nonalcoholic steatohepatitis.



From: Takashima, S., Ikejima, K., Arai, K., Yokokawa, J., Kon, K., Yamashina, S., Watanabe, S. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1105?rss=1

Spinal afferent nerve endings in visceral organs: recent advances

Spinal afferent neurons play a major role in detection and transduction of painful stimuli from internal (visceral) organs. Recent technical advances have made it possible to visualize the endings of spinal afferent axons in visceral organs. Although it is well known that the sensory nerve cell bodies of spinal afferents reside within dorsal root ganglia (DRG), identifying their endings in internal organs has been especially challenging because of a lack of techniques to distinguish them from endings of other extrinsic and intrinsic neurons (sympathetic, parasympathetic, and enteric). We recently developed a surgical approach in live mice that allows selective labeling of spinal afferent axons and their endings, revealing a diverse array of different types of varicose and nonvaricose terminals in visceral organs, particularly the large intestine. In total, 13 different morphological types of endings were distinguished in the mouse distal large intestine, originating from lumbosacral DRG. Interestingly, the stomach, esophagus, bladder, and uterus had less diversity in their types of spinal afferent endings. Taken together, spinal afferent endings (at least in the large intestine) appear to display greater morphological diversity than vagal afferent endings that have previously been extensively studied. We discuss some of the new insights that these findings provide.



From: Spencer, N. J., Zagorodnyuk, V., Brookes, S. J., Hibberd, T. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1056?rss=1

Relationship between gastric motility and liquid mixing in the stomach

The relationship between gastric motility and the mixing of liquid food in the stomach was investigated with a numerical analysis. Three parameters of gastric motility were considered: the propagation velocity, frequency, and terminal acceleration of peristaltic contractions. We simulated gastric flow with an anatomically realistic geometric model of the stomach, considering free surface flow and moving boundaries. When a peristaltic contraction approaches the pylorus, retropulsive flow is generated in the antrum. Flow separation then occurs behind the contraction. The extent of flow separation depends on the Reynolds number (Re), which quantifies the inertial forces due to the peristaltic contractions relative to the viscous forces of the gastric contents; no separation is observed at low Re, while an increase in reattachment length is observed at high Re. While mixing efficiency is nearly constant for low Re, it increases with Re for high Re because of flow separation. Hence, the effect of the propagation velocity, frequency, or terminal acceleration of peristaltic contractions on mixing efficiency increases with Re.



From: Miyagawa, T., Imai, Y., Ishida, S., Ishikawa, T. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1114?rss=1

Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC

LPS-induced microvascular hyperpermeability and hemorrhage play a key role in the development of sepsis, the attenuation of which might be an important strategy to prevent sepsis. However, the current clinical therapies have proven to be inefficient in improving the prognosis for patients with sepsis. Catalpol, an iridoid glycoside extracted from the roots of Rehmannia, has been reported to protect against LPS-induced acute lung injury through a Toll-like receptor-4 (TLR-4)-mediated NF-B signaling pathway. However, it is still unknown whether catalpol can be an effective treatment to ameliorate the LPS-induced microvascular disorder. The present study aimed to investigate the impact of catalpol on LPS-induced mesenteric microvascular disorder and its underlying mechanism. Male Wistar rats were challenged by infusion of LPS (10 mg·kg–1·h–1) through the left femoral vein for 120 min. Post-treatment with catalpol (10 mg/kg) alleviated the LPS-induced microvascular hyperpermeability and hemorrhage; reduced mortality; ameliorated the alteration in the distribution of claudin-5 and the junctional adhesion molecule-1, as well as the degradation of collagen IV and laminin; and attenuated the increase of TLR-4 level, phosphorylations of Src tyrosine kinase, phosphatidyl inositol 3-kinase, focal adhesion kinase, and cathepsin B activation. In vitro study in human umbilical vein endothelial cells verified these results and further revealed that inhibition of TLR-4 and Src each simulated some, but not all, of the effects that catalpol exerted. Besides, surface plasmon resonance showed that catalpol could directly bind to TLR-4 and Src. These results demonstrated that catalpol was able to ameliorate the LPS-induced microvascular barrier damage and hemorrhage by targeting both TLR-4 and Src, thus attenuating the phosphorylation of Src kinase, phosphatidyl inositol 3-kinase, and focal adhesion kinase, as well as cathepsin B activation.



From: Zhang, Y.-P., Pan, C.-S., Yan, L., Liu, Y.-Y., Hu, B.-H., Chang, X., Li, Q., Huang, D.-D., Sun, H.-Y., Fu, G., Sun, K., Fan, J.-Y., Han, J.-Y. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1091?rss=1

Advanced spatiotemporal mapping methods give new insights into the coordination of contractile activity in the stomach of the rat

We used spatiotemporal mapping of strain rate to determine the direction of propagation and amplitudes of the longitudinal and circumferential components of antrocorporal (AC) contractions and fundal contractions in the rat stomach maintained ex vivo and containing a volume of fluid that was within its normal functional capacity. In the region of the greater curvature the longitudinal and circular components of AC contractions propagated synchronously at right angles to the arciform geometric axis of the stomach. However, the configuration of AC contractions was U shaped, neither the circular nor the longitudinal component of contractions being evident in the upper proximal corpus. Similarly, in the distal upper antrum of some preparations, circumferential components propagated more rapidly than longitudinal components. Ongoing "high-frequency, low-amplitude myogenic contractions" were identified in the upper proximal gastric corpus and on the anterior and posterior wall of the fundus. The amplitudes of these contractions were modulated in the occluded stomach by low-frequency pressure waves that occurred spontaneously. Hence the characteristics of phasic contractions vary regionally in the antrum and corpus and a previously undescribed high-frequency contractile component was identified in the proximal corpus and fundus, the latter being modulated in synchrony with cyclic variation in intrafundal pressure in the occluded fundus.



From: Lentle, R. G., Reynolds, G. W., Hulls, C. M., Chambers, J. P. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1064?rss=1

Hydroxylases regulate intestinal fibrosis through the suppression of ERK-mediated TGF-{beta}1 signaling

Fibrosis is a complication of chronic inflammatory disorders such as inflammatory bowel disease, a condition which has limited therapeutic options and often requires surgical intervention. Pharmacologic inhibition of oxygen-sensing prolyl hydroxylases, which confer oxygen sensitivity upon the hypoxia-inducible factor pathway, has recently been shown to have therapeutic potential in colitis, although the mechanisms involved remain unclear. Here, we investigated the impact of hydroxylase inhibition on inflammation-driven fibrosis in a murine colitis model. Mice exposed to dextran sodium sulfate, followed by a period of recovery, developed intestinal fibrosis characterized by alterations in the pattern of collagen deposition and infiltration of activated fibroblasts. Treatment with the hydroxylase inhibitor dimethyloxalylglycine ameliorated fibrosis. TGF-β1 is a key regulator of fibrosis that acts through the activation of fibroblasts. Hydroxylase inhibition reduced TGF-β1-induced expression of fibrotic markers in cultured fibroblasts, suggesting a direct role for hydroxylases in TGF-β1 signaling. This was at least in part due to inhibition of noncanonical activation of extracellular signal-regulated kinase (ERK) signaling. In summary, pharmacologic hydroxylase inhibition ameliorates intestinal fibrosis through suppression of TGF-β1-dependent ERK activation in fibroblasts. We hypothesize that in addition to previously reported immunosupressive effects, hydroxylase inhibitors independently suppress profibrotic pathways.



From: Manresa, M. C., Tambuwala, M. M., Radhakrishnan, P., Harnoss, J. M., Brown, E., Cavadas, M. A., Keogh, C. E., Cheong, A., Barrett, K. E., Cummins, E. P., Schneider, M., Taylor, C. T. http://ajpgi.physiology.org/cgi/content/abstract/311/6/G1076?rss=1

Posture: Align yourself for good health



From: http://www.mayoclinic.org/posture-align-yourself-for-good-health/art-20269950

5 do's and don'ts for staying motivated



From: http://www.mayoclinic.org/5-dos-and-donts-%20for-staying-motivated/art-20270835

John Kasich signs 20-week abortion ban, vetoes stricter provisions

The Ohio governor vetoed the heartbeat bill that would have banned most abortions once a fetal heartbeat is detected

From: http://www.cbsnews.com/news/ohio-governor-john-kasich-signs-20-week-abortion-ban-vetoes-stricter-provisions/

Where you live may determine how you die

A new study breaks down causes of death by county, pinpointing the most pressing local health problems

From: http://www.cbsnews.com/news/where-you-live-may-determine-how-you-die/

President Obama signs 21st Century Cures Act

Joe Biden received a standing ovation from the audience, thanking him for his work in moving the bill forward

From: http://www.cbsnews.com/news/working-president-obama-signs-the-21st-century-cures-act/

Ethics and Integrity at USDA



From: USDA http://www.youtube.com/watch?v=5fWhAQx__5Y

Where You Live May Determine How You Die

Breaking down mortality data by county, most pressing local health problems were pinpointed, study finds



From: http://www.webmd.com/heart-disease/news/20161213/where-you-live-may-determine-how-you-die?src=RSS_PUBLIC

Cushioned Shoe Inserts Won't Guard Against Injury

But custom-made foot orthotics might help, researchers report



From: http://www.webmd.com/pain-management/news/20161213/cushioned-shoe-inserts-wont-guard-against-injury-review?src=RSS_PUBLIC

Posture: Align yourself for good health



From: http://www.mayoclinic.com/posture-align-yourself-for-good-health/art-20269950

5 do's and don'ts for staying motivated



From: http://www.mayoclinic.com/5-dos-and-donts-%20for-staying-motivated/art-20270835

Teen drug use drops to all-time low

New research sheds light on shifting trends in tobacco and alcohol use, as well

From: http://www.cbsnews.com/news/teen-drug-use-drops-to-all-time-low/

Okla. Supreme court tosses law requiring abortion doctors to have hospital privileges

Supreme Court in Oklahoma tossed out a law requiring abortion clinics to have doctors who have admitting privileges at hospitals within 30 miles of their facility

From: http://www.cbsnews.com/news/oklahoma-court-rules-abortion-law-on-hospital-privileges-violates-constitution/

Treatments for Alzheimer’s Proving Elusive

colorful brain image

Research on multiple drugs has failed to pan out, yet scientists doggedly pursue the options for slowing or reversing the ravages of the degenerative brain disorder.



From: http://www.webmd.com/alzheimers/news/20161213/treatments-for-alzheimers-proving-elusive?src=RSS_PUBLIC

The 3 kinds of toys that really help your child

Follow me on Twitter @drClaire

Every holiday season, parents are inundated with ads for toys that will make their child happier, smarter and more successful. They usually involve the latest technology, make noises or are unique in some other way — and are often expensive. Or, they are spin-offs from the latest movie or the latest edition of a popular video game.

As a pediatrician, the ads make me sad — because they are rarely for toys that actually help children be happier, smarter, or more successful. Based on what we know about child health and development, here are the three kinds of toys I wish all parents would give their children.

Toys that require imagination — and that can be used in lots of different ways. The toy should be what gets things started; the rest should be up to the child. Children need to learn to think things through, come up with ideas, and be creative. In the days of video games and Lego sets that are meant to make only one thing, this is getting lost — and it can have all sorts of implications for how children learn and think.

Here are some examples of toys that spur creativity and imagination:

  • blocks (plain wooden ones are great), or building sets that can build lots of different things
  • materials for writing, drawing, and painting — with lots of blank paper. You can buy blank books or blank comic books instead of pads of paper for older children.
  • dollhouses — the simpler the better — with people to go inside them (for both girls and boys).
  • cars, boats, airplanes—simple, non-electronic ones. If you buy tracks, buy ones that can be rearranged. Consider getting a playmat of a town that the cars can drive around.
  • a play kitchen (add an apron and chef’s hat)
  • Dress up clothes — simple things, like capes, robes, wizard’s hats, cowboy hats

If your first reaction is that your child would be bored by these, then all the more reason to buy them. As odd as it sounds, children need to be bored, because boredom breeds creativity. If they are constantly entertained, they will never learn to entertain themselves — and they will miss out on important opportunities to create and explore.

Toys that encourage interaction — especially with their parents and caregivers. One thing we have learned about child development, especially with small children, is that the “serve and return” interactions between children and adults are crucial for building connections in the brain. They are also crucial for building relationships, and strong parent-child relationships make all the difference in the emotional health of children. Building that foundation in childhood also really pays off when they become teens, as a strong relationship with a parent makes them less likely to have sex early or get into trouble.

So buy toys that you can share with your child. Many of the examples above can offer shared experiences; for example, you can play restaurant with your child, or build blocks with them. Here are some other ideas:

  • Games! Whether it’s Checkers or a board game, games can be a great way to play together. There are a myriad of games out there for every age group; doing a “best family board games” Google search will get you lots of suggestions.
  • a model you can build together (make sure your child can do it too, so it’s not just you), or something else you make together
  • a tent — either a big one to camp in together, or a smaller one that you can use in the living room and hang out in together
  • walkie-talkies

Toys that get your child moving. Not only is exercise important for your child’s health, the exercise habits started in childhood can last a lifetime. So wrap up a few that will encourage exercise! Some examples:

  • a ball (soccer ball, baseball, basketball) with something to use it with (like a bat, mitt or basket).
  • jump ropes
  • roller skates or ice skates
  • a scooter or bike (remember to pick up a helmet, too)

If you get moving with them, all the better.

The post The 3 kinds of toys that really help your child appeared first on Harvard Health Blog.



From: Claire McCarthy, MD http://www.health.harvard.edu/blog/3-kinds-toys-really-help-child-2016121310853

Keeping the human connection in medicine

Last month, the New England Journal of Medicine published a thoughtful essay by David Rosenthal and Abraham Verghese on the many changes in how doctors are trained and how they practice medicine. Efforts to improve efficiency and accuracy — including the introduction of electronic medical records — offer benefits, and pose some complicated problems.

Doctors need to learn and do more, more than ever

The health care system strives to deliver better care while keeping costs down. Advances in medical science and technology mean there is ever more information for a doctor to know, and policies to curb waste have limited the amount of time we have to learn it all. Monique Tello wrote about this issue last month; it’s why your doctor is always at the computer. But more than that, these competing goals have had real consequences for how doctors work, how we think, how we relate to our patients and colleagues, and how we feel about our profession.

An example: I’m a hospitalist. It’s a relatively new field in medicine, a product of exactly these forces. Two decades ago, when patients were hospitalized, their primary care doctors would see them in the hospital, in the morning, before returning to clinic for the day. Residents or nurses, often without immediate supervision, managed minute-to-minute affairs. But the culture and standards of practice have changed. We’ve decided that it’s better to have fully-trained doctors in the hospital all day. In an emergency, I can be at the bedside in an instant. Residents and nurses get more active supervision. Primary care doctors, who have seen their reimbursements cut, can spend more time seeing patients. But there are downsides. The people I see in the hospital often don’t know me, and I don’t know them. And when a person leaves the hospital, his doctor may not know what I’ve done and why. So, we’ve replaced one set of challenges with another: making sure that there’s good communication between hospitals and clinics.

Electronic medical records can make that communication easier. When a patient comes to me in the hospital, I have immediate access to their entire chart. I can see records from every clinic visit, lab test, x-ray or CT scan, a list of all their possible diagnoses and the medications prescribed to treat them. It’s useful to look at this information before I meet someone new. After all, if you’re sick and uncomfortable, you don’t want to have to repeat the same story to every new doctor you see. And it’s reassuring to know that the doctor you’re meeting for the first time has taken the time and effort to get to know the particulars of your situation. What’s more, those records make my job easier. My patients may not remember the names and doses of all of their medications. No problem, I can look it all up.

But the things that make us more efficient may challenge the ability to develop and maintain personal connections

But something valuable gets lost. Maybe there’s a reason a patient can’t remember the names of her medications. Sometimes digging a little bit further can turn up a clue that there’s something more going on. But those clues come up in face-to-face conversations, and over time, not with a glance at a computer screen. Dr. Jerome Groopman describes another challenge in his book How Doctors Think. Seeing what other doctors have written about a patient can trap us into thinking about their illness in the same way, and blind us to alternative diagnoses. Sometimes the best way to work is to start fresh, and to let your patient tell her story from the beginning.

And then there’s the problem of distance. We have more and more tests that promise more accurate diagnoses, but require time to coordinate and review. Computerized notes and emails make it easy for doctors to communicate with each other, but have replaced conversations between colleagues. As doctors are increasingly isolated from both patients and each other, they have become demoralized and burned out.

At its best, being a doctor is an extraordinary and intimate privilege. We build relationships with our patients and see them through times of both joy and suffering; our relationships with each other help us through the same. It’s hard to do that in a way that’s truly satisfying when we spend most of the day at the computer screen. Rosenthal and Verghese don’t see an easy fix for these problems. They are largely structural and built into the practice of medicine. But they charge us to remember that the meaning of medicine is in its human connections. Whatever comes next, both doctors and patients should fight to hold on to that.

The post Keeping the human connection in medicine appeared first on Harvard Health Blog.



From: John Sanford Limouze, MD http://www.health.harvard.edu/blog/keeping-the-human-connection-in-medicine-2016121210837

Fewer chubby babies a hopeful sign in obesity fight

A government food program serving millions of kids appears to be working, with fewer youngsters at risk for obesity, according to a new study

From: http://www.cbsnews.com/news/fewer-chubby-babies-offer-hopeful-sign-in-fight-against-obesity/

Could statins help cut Alzheimer's risk?

A new study suggests there may be a connection, though a number of factors appear to affect who benefits most

From: http://www.cbsnews.com/news/could-statins-help-cut-alzheimers-risk/

U.S. Mumps Cases at 10-Year High: CDC

U.S. Mumps Cases at 10-Year High: CDC



From: http://www.webmd.com/children/news/20161213/us-mumps-cases?src=RSS_PUBLIC

Posture: Align yourself for good health



From: http://www.mayoclinic.org/posture-align-yourself-for-good-health/art-20269950

5 do's and don'ts for staying motivated



From: http://www.mayoclinic.org/5-dos-and-donts-%20for-staying-motivated/art-20270835

Opioid-Dependent Babies Up at Rural Hospitals

Cases have skyrocketed because of widespread maternal drug abuse, study says



From: http://www.webmd.com/mental-health/addiction/news/20161212/rural-hospitals-see-surge-in-opioid-dependent-babies?src=RSS_PUBLIC

Just 40% of Americans Have Flu Shot This Season

CDC urges everyone to get a shot, especially children, pregnant women and folks over 50



From: http://www.webmd.com/cold-and-flu/news/20161212/just-40-percent-of-americans-vaccinated-for-flu-this-season?src=RSS_PUBLIC

More parts of tough Florida abortion law challenged

Law requires groups to register and pay a fee if they advise or help women seeking abortions; ACLU calls it unconstitutional

From: http://www.cbsnews.com/news/federal-judge-asked-block-more-parts-florida-abortion-law/

Doctors track "explosion" of opioid-addicted newborns

Newborn babies addicted to opioids are being born at record rates – especially in rural areas

From: http://www.cbsnews.com/news/opioid-epidemic-newborn-babies-mothers-addicted-to-painkillers/

May Clinic Minute: Avoid holiday allergy issues



From: Mayo Clinic http://www.youtube.com/watch?v=t7BfUPKf2A8

BDA Student Council Rep John Budding



From: BritishDietetic http://www.youtube.com/watch?v=srBtwqNSX30

Drug Use by U.S. Teens Drops to All-Time Low

Use of tobacco and alcohol down significantly, too, federal report finds



From: http://www.webmd.com/mental-health/addiction/news/20161213/drug-use-by-us-teens-drops-to-all-time-low?src=RSS_PUBLIC

The 3 kinds of toys that really help your child

Follow me on Twitter @drClaire

Every holiday season, parents are inundated with ads for toys that will make their child happier, smarter and more successful. They usually involve the latest technology, make noises or are unique in some other way — and are often expensive. Or, they are spin-offs from the latest movie or the latest edition of a popular video game.

As a pediatrician, the ads make me sad — because they are rarely for toys that actually help children be happier, smarter, or more successful. Based on what we know about child health and development, here are the three kinds of toys I wish all parents would give their children.

Toys that require imagination — and that can be used in lots of different ways. The toy should be what gets things started; the rest should be up to the child. Children need to learn to think things through, come up with ideas, and be creative. In the days of video games and Lego sets that are meant to make only one thing, this is getting lost — and it can have all sorts of implications for how children learn and think.

Here are some examples of toys that spur creativity and imagination:

  • blocks (plain wooden ones are great), or building sets that can build lots of different things
  • materials for writing, drawing, and painting — with lots of blank paper. You can buy blank books or blank comic books instead of pads of paper for older children.
  • dollhouses — the simpler the better — with people to go inside them (for both girls and boys).
  • cars, boats, airplanes—simple, non-electronic ones. If you buy tracks, buy ones that can be rearranged. Consider getting a playmat of a town that the cars can drive around.
  • a play kitchen (add an apron and chef’s hat)
  • Dress up clothes — simple things, like capes, robes, wizard’s hats, cowboy hats

If your first reaction is that your child would be bored by these, then all the more reason to buy them. As odd as it sounds, children need to be bored, because boredom breeds creativity. If they are constantly entertained, they will never learn to entertain themselves — and they will miss out on important opportunities to create and explore.

Toys that encourage interaction — especially with their parents and caregivers. One thing we have learned about child development, especially with small children, is that the “serve and return” interactions between children and adults are crucial for building connections in the brain. They are also crucial for building relationships, and strong parent-child relationships make all the difference in the emotional health of children. Building that foundation in childhood also really pays off when they become teens, as a strong relationship with a parent makes them less likely to have sex early or get into trouble.

So buy toys that you can share with your child. Many of the examples above can offer shared experiences; for example, you can play restaurant with your child, or build blocks with them. Here are some other ideas:

  • Games! Whether it’s Checkers or a board game, games can be a great way to play together. There are a myriad of games out there for every age group; doing a “best family board games” Google search will get you lots of suggestions.
  • a model you can build together (make sure your child can do it too, so it’s not just you), or something else you make together
  • a tent — either a big one to camp in together, or a smaller one that you can use in the living room and hang out in together
  • walkie-talkies

Toys that get your child moving. Not only is exercise important for your child’s health, the exercise habits started in childhood can last a lifetime. So wrap up a few that will encourage exercise! Some examples:

  • a ball (soccer ball, baseball, basketball) with something to use it with (like a bat, mitt or basket).
  • jump ropes
  • roller skates or ice skates
  • a scooter or bike (remember to pick up a helmet, too)

If you get moving with them, all the better.

The post The 3 kinds of toys that really help your child appeared first on Harvard Health Blog.



From: Claire McCarthy, MD http://www.health.harvard.edu/blog/3-kinds-toys-really-help-child-2016121310853

Malaria control improves for vulnerable in Africa, but global progress off-track

WHO’s World Malaria Report 2016 reveals that children and pregnant women in sub-Saharan Africa have greater access to effective malaria control.

From: http://www.who.int/entity/mediacentre/news/releases/2016/malaria-control-africa/en/index.html

Posture: Align yourself for good health



From: http://www.mayoclinic.com/posture-align-yourself-for-good-health/art-20269950

5 do's and don'ts for staying motivated



From: http://www.mayoclinic.com/5-dos-and-donts-%20for-staying-motivated/art-20270835

Cuisinart food processors recalled due to laceration hazard

Voluntary recall involves some Cuisinart food processors sold from 1996 through December 2015 -- check out the full list of models here

From: http://www.cbsnews.com/news/cuisinart-food-processors-recalled-by-conair-due-to-laceration-hazard/

Posture: Align yourself for good health



From: http://www.mayoclinic.org/posture-align-yourself-for-good-health/art-20269950

5 do's and don'ts for staying motivated



From: http://www.mayoclinic.org/5-dos-and-donts-%20for-staying-motivated/art-20270835

Keeping the human connection in medicine

Last month, the New England Journal of Medicine published a thoughtful essay by David Rosenthal and Abraham Verghese on the many changes in how doctors are trained and how they practice medicine. Efforts to improve efficiency and accuracy — including the introduction of electronic medical records — offer benefits, and pose some complicated problems.

Doctors need to learn and do more, more than ever

The health care system strives to deliver better care while keeping costs down. Advances in medical science and technology mean there is ever more information for a doctor to know, and policies to curb waste have limited the amount of time we have to learn it all. Monique Tello wrote about this issue last month; it’s why your doctor is always at the computer. But more than that, these competing goals have had real consequences for how doctors work, how we think, how we relate to our patients and colleagues, and how we feel about our profession.

An example: I’m a hospitalist. It’s a relatively new field in medicine, a product of exactly these forces. Two decades ago, when patients were hospitalized, their primary care doctors would see them in the hospital, in the morning, before returning to clinic for the day. Residents or nurses, often without immediate supervision, managed minute-to-minute affairs. But the culture and standards of practice have changed. We’ve decided that it’s better to have fully-trained doctors in the hospital all day. In an emergency, I can be at the bedside in an instant. Residents and nurses get more active supervision. Primary care doctors, who have seen their reimbursements cut, can spend more time seeing patients. But there are downsides. The people I see in the hospital often don’t know me, and I don’t know them. And when a person leaves the hospital, his doctor may not know what I’ve done and why. So, we’ve replaced one set of challenges with another: making sure that there’s good communication between hospitals and clinics.

Electronic medical records can make that communication easier. When a patient comes to me in the hospital, I have immediate access to their entire chart. I can see records from every clinic visit, lab test, x-ray or CT scan, a list of all their possible diagnoses and the medications prescribed to treat them. It’s useful to look at this information before I meet someone new. After all, if you’re sick and uncomfortable, you don’t want to have to repeat the same story to every new doctor you see. And it’s reassuring to know that the doctor you’re meeting for the first time has taken the time and effort to get to know the particulars of your situation. What’s more, those records make my job easier. My patients may not remember the names and doses of all of their medications. No problem, I can look it all up.

But the things that make us more efficient may challenge the ability to develop and maintain personal connections

But something valuable gets lost. Maybe there’s a reason a patient can’t remember the names of her medications. Sometimes digging a little bit further can turn up a clue that there’s something more going on. But those clues come up in face-to-face conversations, and over time, not with a glance at a computer screen. Dr. Jerome Groopman describes another challenge in his book How Doctors Think. Seeing what other doctors have written about a patient can trap us into thinking about their illness in the same way, and blind us to alternative diagnoses. Sometimes the best way to work is to start fresh, and to let your patient tell her story from the beginning.

And then there’s the problem of distance. We have more and more tests that promise more accurate diagnoses, but require time to coordinate and review. Computerized notes and emails make it easy for doctors to communicate with each other, but have replaced conversations between colleagues. As doctors are increasingly isolated from both patients and each other, they have become demoralized and burned out.

At its best, being a doctor is an extraordinary and intimate privilege. We build relationships with our patients and see them through times of both joy and suffering; our relationships with each other help us through the same. It’s hard to do that in a way that’s truly satisfying when we spend most of the day at the computer screen. Rosenthal and Verghese don’t see an easy fix for these problems. They are largely structural and built into the practice of medicine. But they charge us to remember that the meaning of medicine is in its human connections. Whatever comes next, both doctors and patients should fight to hold on to that.

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From: John Sanford Limouze, MD http://www.health.harvard.edu/blog/keeping-the-human-connection-in-medicine-2016121210837