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Friday, January 22, 2016
Flint mother: I'm worried my son will wake up different
From: http://www.cbsnews.com/news/flint-michigan-water-lead-mother-im-worried-my-son-will-wake-up-different/
1 dead from listeria outbreak linked to Dole salads
From: http://www.cbsnews.com/news/listeria-outbreak-linked-to-dole-salads/
Is There Lead in Your Water?
It’s not just Flint, MI. The drinking water of many cities across the U.S. could have high lead levels, and you wouldn’t necessarily know it.
From: http://www.webmd.com/children/news/20160122/is-there-lead-in-your-water?src=RSS_PUBLIC
Zika virus raises new worry about paralysis
From: http://www.cbsnews.com/news/zika-virus-guillain-barre-syndrome-paralysis/
Flexible robot could make surgery, recovery easier
From: http://www.cbsnews.com/news/flexible-robot-could-make-surgery-recovery-easier/
Mayo Clinic Minute: What to Do if Your Baby has Eczema
From: Mayo Clinic http://www.youtube.com/watch?v=LpHw-hKE8No
Migraines May Worsen as Menopause Approaches
Researchers say hormonal changes and painkiller overuse may be to blame
From: http://www.webmd.com/migraines-headaches/news/20160122/migraines-may-worsen-as-menopause-approaches?src=RSS_PUBLIC
‘Single-Payer’ Debated: What Does That Mean?
The phrase often used for government-run health care means different things to different people. Here are five points to help explain the Democrats’ policy clash.
From: http://www.webmd.com/health-insurance/20160122/democratic-candidates-debate-singlepayer-but-what-does-that-mean?src=RSS_PUBLIC
The growing movement to track employee health
From: http://www.cbsnews.com/news/the-growing-movement-to-track-employee-health/
Flexible robot a new advance in surgery
From: http://www.cbsnews.com/videos/flexible-robot-a-new-advance-in-surgery/
Millions get cancer screening tests they don't need
From: http://www.cbsnews.com/news/millions-get-cancer-screening-tests-they-dont-really-need/
Winter Hazard: Carbon Monoxide Poisoning
From: Mayo Clinic http://www.youtube.com/watch?v=5BoVLCeNkhw
Clot-Busters Might Help These Stroke Patients
Study finds favorable results among older adults who already had health problems
From: http://www.webmd.com/stroke/news/20160122/clot-busters-might-be-useful-for-previously-dependent-stroke-patients?src=RSS_PUBLIC
Anti-depressants for teens: A second look
Those of you who re my last blog may remember that I talked about how upbeat friends can help boost your teenager’s mood. But there’s an important and reasonable follow-up question. What if, despite your best efforts to help your teen’s mood and sense of well-being, his or her doctor recommends an antidepressant? I want to explore this further, both to help you better understand your teenager’s health and to illustrate a new approach to dealing with controversial data.
Parents of teens, you are not alone in worrying about whether an antidepressant is the right choice for your child. Your doctor is likewise worried about how to best guide you on this issue. Will an antidepressant help your teen feel better, or could it actually worsen his or her depression? To get to the heart of the matter, parents and doctors are worried about suicide. Some studies report no increase in rates of suicidal thoughts in teens taking antidepressants, while others suggest the opposite. How can there be so much disagreement on such a critical issue?
A recent study published in the journal BMJ attempts to pick apart this highly controversial issue. It’s called “Efficacy and Harms of Paroxetine and Imipramine in Treatment of Major Depression in Adolescence,” and it’s one of the earliest in a set of studies that will likely be very important to the medical literature. It is part of an initiative called Restoring Invisible and Abandoned Trials (RIAT), which calls on researchers to re-analyze data from unpublished trials or published trials with poor methodology. The goal is to correct misleading information by examining data in a more scientific way.
What went wrong for these trials the first time around?
There are two main issues. First, many of these trials were funded by drug companies or large academic institutions. Financial or intellectual incentive to interpret the data in a specific way presents an inherent — if often unintentional — bias. This might happen when researchers set out to study a drug they have created or that they own. Pharmaceutical-company–funded studies are exceedingly common in the medical literature. Second, only about half of the results of clinical trials are ever published. Yet those data are out there, and if analyzed, could help fill knowledge gaps and improve medical care. This gap in published data is known as reporting bias, and it is generally considered bad science.
“Restoring Study 329”
The study on teens and antidepressants we’re looking at today aimed to re-analyze the data from research initially published in 2001 by Smith Kline Beecham, a pharmaceutical company. The study looked at the effectiveness and safety of two antidepressants in teenagers. One of the drugs was paroxetine (Paxil), which may sound familiar to you. The other drug was called imipramine. It’s probably less familiar to you because doctors no longer use it much to treat depression. The original research reported that paroxetine was safe and effective for adolescents, and did not lead to an increase in teen suicide. In “Restoring Study 329”, researchers re-analyzed the data (which was willingly provided by Smith Kline Beecham). Upon this second look, researchers found that paroxetine was not any more effective than a sugar pill, and it did lead to clinically significant increases in harm, including suicidal thoughts or behavior in adolescent patients.
Why did they find such different results?
Partway during the initial study, the investigators made some subtle changes to the research protocols. In the re-analysis, the researchers stuck like glue to the original study protocol. Second, the original authors reported on adverse events in only 5% of their study participants. This time, researchers looked at adverse events across all study participants. Finally, the original researchers grouped adverse events in ways that may have been misleading. For example, they did not separate neurological side effects (such as headache, a mild side effect) from psychiatric side effects (such as suicidal thoughts, a more serious side effect). Lumping these groups together watered down the percentage of teens who had thoughts of suicide. By carefully separating out these different types of side effects, the re-analysis more accurately reflected the number of psychiatric events.
What Restoring Study 329 means for parents — and teens
We have no evidence that the original researchers tried to purposefully mislead anybody. But parents (and doctors!) understandably need to know whether starting an antidepressant may raise the risk of thoughts of suicide in teens, and the original study likely downplayed this real risk. Whether or not to start a teenager on an antidepressant is a highly personal decision that depends heavily on the situation for each individual teen. This study highlights the importance of talking to your trusted doctor about the things you hear before just accepting the version of results presented to you. As a doctor, I look forward to more studies that re-examine our current understanding of research data. I hope they will help provide the important information I need to best guide my patients.
Related Post:
The post Anti-depressants for teens: A second look appeared first on Harvard Health Blog.
From: Nandini Mani, MD http://www.health.harvard.edu/blog/anti-depressants-for-teens-201601229018
Stomach Birth Defect Rate Doubled Over 2 Decades
Gastroschisis, a hole in the abdominal wall, more common in babies born to teen mothers
From: http://www.webmd.com/parenting/baby/news/20160121/rate-of-severe-stomach-birth-defect-doubled-over-two-decades-cdc?src=RSS_PUBLIC
Excess Weight Linked to Blood Clot Risk in Kids
One in three children with a clot was obese, study finds
From: http://www.webmd.com/children/news/20160121/excess-weight-linked-to-blood-clot-risk-in-kids?src=RSS_PUBLIC
Check Your Risk for Diabetes, CDC Urges
Prediabetes awareness campaign launched nationwide
From: http://www.webmd.com/diabetes/news/20160121/check-your-risk-for-diabetes-cdc-urges?src=RSS_PUBLIC
Cough Syrup with Morphine Recalled
Drug Makers, Governments Sign Deal to Fight Drug-Resistant Infections Sierra Leone Reports Another Ebola Case
From: http://www.webmd.com/cold-and-flu/news/20160121/cough-syrup-morphine-recall?src=RSS_PUBLIC
Frostbite and 5 other winter hazard to avoid
From: http://www.cbsnews.com/news/frostbite-hypothermia-winter-hazards-to-avoid/
Melinda Gates: One issue key in conquering poverty
From: http://www.cbsnews.com/news/davos-2016-world-economic-forum-melinda-gates-upstream-investments/