"Biggest Loser" study: Why keeping weight off is so hard

Six years after starring on "The Biggest Loser," most competitors gained back weight

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fbiggest-loser-study-why-staying-slim-is-so-hard%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Boy dies of cancer after getting hundreds of birthday cards

Lucas "Bear" Cervone inspired people from all over the world to send him cards as he battled an incurable cancer

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fchicago-boy-lucas-bear-cervone-dies-of-cancer-after-getting-hundreds-of-birthday-cards%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Millions of antibiotic prescriptions each year are unnecessary

Antibiotic resistance leads to thousands of deaths each year, and overuse is the main driver, researchers say

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fmillions-of-antibiotic-prescriptions-each-year-unnecessary-study-finds%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Expectant Mom's Flu Shot Protects 2

Infants benefit when a woman gets her influenza immunization during pregnancy, study confirms

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fbaby%2Fnews%2F20160503%2Fexpectant-moms-flu-shot-protects-2%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

USDA Awards $16 Million for Research into Sustainable Crop and Livestock Production Methods

WASHINGTON, May 3, 2016 – The U.S. Department of Agriculture (USDA) today awarded $16.5 million in grants to support research into methods for boosting agriculture productivity and ensuring food security in the face of pests, diseases and a changing climate. In addition, USDA announced that it is seeking applications for the next round of projects, which will focus on pollinator health and plant and animal phenomics. The grants are made available through the Agriculture and Food Research Initiative (AFRI), administered by USDA’s National Institute of Food and Agriculture (NIFA).

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.usda.gov%2Fwps%2Fportal%2Fusda%2Fusdahome%3Fcontentid%3D2016%2F05%2F0101.xml%26amp%3Bcontentidonly%3Dtrue&key=ddaed8f51db7bb1330a6f6de768a69b8

Desperate for Shut-Eye?

Physicians' group recommends cognitive behavioral therapy before drugs for insomnia

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fsleep-disorders%2Fnews%2F20160502%2Fdesperate-for-shut-eye%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Opioid Epidemic Fueling Hospitalizations, Costs

New research sheds light on the growing costs to the health care system associated with painkiller and heroin abuse.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.webmd.com%2Fmental-health%2Faddiction%2Fnews%2F20160502%2Fopioid-epidemic-fueling-hospitalizations-hospital-costs%3Fsrc%3DRSS_PUBLIC&key=ddaed8f51db7bb1330a6f6de768a69b8

Jury awards cancer survivor $55M in J&J talc lawsuit

Johnson & Johnson vows to appeal the ruling

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fjury-awards-cancer-survivor-55m-in-johnson-johnson-talcum-powder-lawsuit%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Johnson & Johnson slammed again in a talcum powder lawsuit

For second time in less than 3 months, jury orders company to pay tens of millions to woman claiming its talcum powder caused her ovarian cancer; J&J appealing

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fjohnson-and-johnson-slammed-again-in-a-talcum-powder-lawsuit%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice

The pathogenesis of necrotizing enterocolitis (NEC), a common gastrointestinal disease affecting premature infants, remains poorly understood. We previously found that intestinal VEGF-A expression is decreased in human NEC samples and in a neonatal mouse NEC model prior to detectable histological injury. Therefore, we hypothesized that lack of VEGF receptor 2 (VEGFR2) signaling facilitates neonatal intestinal injury by impairing intestinal microvasculature development. Here, we found that intestinal VEGF-A and its receptor, VEGFR2, were highly expressed at the end of fetal life and significantly decreased after birth in mice. Furthermore, selective inhibition of VEGFR2 kinase activity and exposure to a neonatal NEC protocol significantly decreased the density of the intestinal microvascular network, which was further reduced when both interventions were provided together. Furthermore, VEGFR2 inhibition resulted in greater mortality and incidence of severe injury in pups submitted to the NEC model. The percentage of lamina propria endothelial cells was decreased during NEC induction, and further decreased when VEGFR2 signaling was inhibited. This was associated with decreased endothelial cell proliferation rather than apoptosis. In conclusion, we found that VEGF-A and VEGFR2 proteins are highly expressed in the intestine before birth, and are significantly downregulated in the immediate neonatal period. Furthermore, VEGFR2 signaling is necessary to maintain the integrity of the intestinal mucosal microvasculature during the postnatal period and lack of VEGFR2 signaling predisposes to NEC in neonatal mice.

From: Yan, X., Managlia, E., Liu, S. X., Tan, X.-D., Wang, X., Marek, C., De Plaen, I. G. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F310%2F9%2FG716%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

Selective portal vein injection for the design of syngeneic models of liver malignancy

Liver metastases are the most frequent cause of death due to colorectal cancer (CRC). Syngeneic orthotopic animal models, based on the grafting of cancer cells or tissue in host liver, are efficient systems for studying liver tumors and their (patho)physiological environment. Here we describe selective portal vein injection as a novel tool to generate syngeneic orthotopic models of liver tumors that avoid most of the weaknesses of existing syngeneic models. By combining portal vein injection of cancer cells with the selective clamping of distal liver lobes, tumor growth is limited to specific lobes. When applied on MC-38 CRC cells and their mouse host C57BL6, selective portal vein injection leads with 100% penetrance to MRI-detectable tumors within 1 wk, followed by a steady growth until the time of death (survival ~7 wk) in the absence of extrahepatic disease. Similar results were obtained using CT-26 cells and their syngeneic Balb/c hosts. As a proof of principle, lobe-restricted liver tumors were also generated using Hepa1-6 (C57BL6-syngeneic) and TIB-75 (Balb/c-syngeneic) hepatocellular cancer cells, demonstrating the general applicability of selective portal vein injection for the induction of malignant liver tumors. Selective portal vein injection is technically straightforward, enables liver invasion via anatomical routes, preserves liver function, and provides unaffected liver tissue. The tumor models are reproducible and highly penetrant, with survival mainly dependent on the growth of lobe-restricted liver malignancy. These models enable biological studies and preclinical testing within short periods of time.

From: Limani, P., Borgeaud, N., Linecker, M., Tschuor, C., Kachaylo, E., Schlegel, A., Jang, J.-H., Ungethüm, U., Montani, M., Graf, R., Humar, B., Clavien, P.-A. http://redirect.viglink.com?u=http%3A%2F%2Fajpgi.physiology.org%2Fcgi%2Fcontent%2Fabstract%2F310%2F9%2FG682%3Frss%3D1&key=ddaed8f51db7bb1330a6f6de768a69b8

"Asian tiger" mosquito could carry Zika virus to more U.S. states

There are new fears about the spread of the mosquito-borne Zika virus

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fvideos%2Fasian-tiger-mosquito-could-carry-zika-virus-to-more-u-s-states%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

New Zika alert: Beware the Asian tiger mosquito

CDC says Zika virus has been found in a second mosquito, Aedes albopictus, which is found in more states of the U.S.

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fzika-virus-may-be-carried-farther-north-than-first-thought%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

CDC investigating after 97 fall sick on Disney cruise ship

Stomach bug outbreak aboard the Disney Wonder cruise ship impacted both passengers and crew members, CDC says

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fcdc-investigating-after-97-fall-sick-on-disney-cruise-ship%2F&key=ddaed8f51db7bb1330a6f6de768a69b8

Chronic insomnia? Why pills may not be the answer

Before you look to medication to get some much-needed shut-eye, doctors say you should try this first

From: http://redirect.viglink.com?u=http%3A%2F%2Fwww.cbsnews.com%2Fnews%2Fchronic-insomnia-why-pills-may-not-be-the-answer%2F&key=ddaed8f51db7bb1330a6f6de768a69b8